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Cytokines from the IL-1 family perform important functions in innate immune reactions, but can also be involved in chronic inflammatory diseases. This Review highlights the roles of IL-1 family members in rheumatic diseases and potential therapeutic approaches to targeting them.
Review Article 04 September Data from clinical trials of novel targeted therapies for psoriatic arthritis and other autoimmune diseases, which have produced sometimes surprising results, can inform our understanding of the immunopathogenesis of these diseases and help to identify the most relevant therapeutic targets. New strategies are under development to help treat and prevent this disease.
Review Article 27 August Rheumatoid arthritis RA -associated lung disease is difficult to treat and is associated with increased morbidity and mortality. A better understanding of the pathogenic pathways involved in lung disease in patients with RA should aid the development of specific therapies. Review Article 09 August Cutaneous lupus erythematosus encompasses a broad spectrum of skin lesions that can occur in isolation or as a manifestation of systemic lupus erythematosus.
Insights into the cellular and molecular pathogenesis of cutaneous lupus erythematosus have triggered the development of new therapeutic strategies. Research Highlight 04 October Research Highlight 01 October Research Highlight 30 September Research Highlight 26 September Duke Kunshan University.
The University of Chicago UChicago. This article has been cited by other articles in PMC. Abstract Rheumatic and musculoskeletal diseases RMDs represent a multitude of degenerative, inflammatory and auto-immune conditions affecting millions of people worldwide. Electronic supplementary material The online version of this article doi Introduction The term rheumatic and musculoskeletal diseases RMDs largely encompasses over one hundred degenerative, inflammatory and auto-immune conditions which in their most advanced form are associated with severe pain, joint damage, disability and even death.
Open in a separate window. Rheumatic and musculoskeletal diseases RMDs and their estimated prevalence. Summary of the global challenges and opportunities facing rheumatology today. Methodology A preliminary PubMed literature search focusing on challenges in the areas of RMDs clinical care, education and research was conducted to identify key questions for the authors to address. Challenges within the clinical care services According to the WHO, a key component of a well-functioning health system is to provide equitable access to people-centred care [ 12 ]. Table 1 Estimated rheumatologist workforce across different countries.
Education of rheumatologists and other experts in RMD care Successful education in the RMDs requires a collaborative, constructive, and contextual approach, aimed at providing education across professions.
Specialist training Collaborations between rheumatology associations and universities could help strengthen existing teaching, provide core knowledge of the RMDs to all practitioners and encourage rheumatology as a specialty within that region. Continuing education Regional and national rheumatology leagues should help to deliver courses with clear curricular goals.
Patient awareness of RMDs In some areas of the world, a lack of basic education and literacy, poorer socioeconomic status and cultural beliefs can influence the decision of patients to seek medical attention from a PCP, or they may only seek help from alternate care practitioners [ 9 ]. Research challenges The impact of financial, political, social, or environmental factors on the opportunity to conduct clinical, epidemiological, as well as basic and translational research creates major challenges worldwide.
Clinical trials research Ethnicity may influence the manifestation of various RMDs, due to underlying genetic differences, environmental factors, cultures and socioeconomic status [ 42 ]. Table 2 Number of registered clinical trials listed on ClinicalTrials. Studies with no locations are not included; studies with multiple locations are included in each region containing locations a Latin America values obtained by adding number of trials in Central America and South America.
Investigator-initiated research There are many existing programmes to support investigator-initiated RMDs research including the Canadian Initiative for Outcomes in Rheumatology Care CIORA which offers awards to new clinicians to carry out independent arthritis research. Epidemiological research Real-life efficacy and safety data from registries provide a valuable source of data for the RMDs. Conclusions The high prevalence and burden of RMDs presents a number of global challenges for the practice of rheumatology and more generally for chronic diseases.
Conflict of interest All authors declare no conflict of interest related to this manuscript. Footnotes 1 For the purpose of this manuscript, developing countries are defined by World Bank criteria as low- and middle-income economies, i.
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Anne-Priscille Trouvin Serge Perrot. Emire Seyahi. Purchase access Subscribe now. It also does not speak to potential cost savings in other areas, such as office phones, cell phones, revenue cycle, EMR purchases if needed, etc. The author declares no conflict of interest.
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